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New developments in diagnosis, risk assessment and ..., 2020-3-1 · The first 2 cases of response to daratumumab were reported in 2016 . In a case series of 25 previously treated AL patients, 72% had cardiac involvement. Daratumumab was given as monotherapy and patients received a median of three prior lines of therapy. The overall hematologic response rate was 76% (CR 36%, VGPR 24%).