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.freepatentsonline.com, 2020-2-13 · 1. A method for modulating the level of expression of a protein, the method comprising: inserting a polynucleotide sequence into a nucleic acid sequence encoding a first protein oTargeting of G, 2020-7-1 · In fact, the degree of apoptotic loss of lymphocytes has been shown to be correlated with the severity of sepsis (Drewry et al., 2014). Pharmacological approaches that block the interaction of PD-L1 with PD1 and reduce lymphocytic apoptosis have been shown to be beneficial in experimental models of sepsis (Patil, Guo, Luan, & Sherwood, 2017)..

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